Article details

Journal
Zeszyty naukowe PŁ, Chemia Spożywcza i Biotechnologia
Zeszyt 70
Year
2006
Title
The study of the interactions between naproxen and N-acetyl-L-tyrosine ethyl ester
Authors

Dorota Sobczuk
Institute of General Food Chemistry
Technical University of Łódź, Poland
Rebecca Craig
The School of Pharmacy
The Queen's University of Belfast
Medical Biology Centre, Belfast replique montre omega
BT9 7BL, Northern Ireland, U.K.
Marta Nogueroles
Facultad de Ciencias
Universidad de Alicante, Alicante, Spain
Slavica Radišić
Department of Pharmacy
Faculty of Medicine, Banja Luka, 78000 Banja Luka, Bosnia
Boheng Shen
School of Biosciences
University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K.
Susanne Simon
Biozentrum of the University of Basel
CH-4056 Basel, Switzerland

 


Pages: 23 - 36
Abstract

The interaction between naproxen and N-acetyl-L-tyrosine ethyl ester was investigated using UV-Vis absorption and fluorescence methods and the results indicate that an interaction is present in the ground state. Hydrogen bond formation between these two molecules in complexation was illustrated by the computer optimised complex. This theory was supported by the increased fluorescence lifetime decay observed, the Gibbs free energy for complexation and also by the geometry of the complex.

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